| 09/08/2026 | KAA Gent | KV Mechelen | 2 – 0 | eerste nederlaag |
| 16/08/2026 | KV Mechelen | R. Standard de Liège | 3 – 3 | |
| 22/08/2026 | Sporting du Pays de Charleroi | KV Mechelen | 2 – 0 | |
| 29/08/2026 | Raal La Louvière | KV Mechelen | 2 – 2 | |
| 05/09/2026 | KV Mechelen | KVC Westerlo | 0 – 4 | |
| 11/09/2026 | KV Mechelen | RSC Anderlecht | 0 – 1 | |
| 19/09/2026 | KFC Lommelse SK | KV Mechelen | ||
| 11/10/2026 | KV Mechelen | K. Sint-Truidense VV | ||
| 23/10/2026 | KV Kortrijk | KV Mechelen | ||
| 31/10/2026 | KV Mechelen | KRC Genk | ||
| 07/11/2026 | Oud-Heverlee Leuven | KV Mechelen | ||
| 21/11/2026 | KV Mechelen | Club Brugge KV | ||
| 28/11/2026 | Cercle Brugge KSV | KV Mechelen | ||
| 13/12/2026 | KV Mechelen | R. Union Saint-Gilloise | ||
| 19/12/2026 | SK Beveren | KV Mechelen | ||
| 27/12/2026 | KV Mechelen | SV Zulte Waregem | ||
| 16/01/2027 | R. Antwerp FC | KV Mechelen | ||
| 22-24/01/2027 | KV Mechelen | Lommel SK | ||
| 29-31/01/2027 | K. Sint-Truidense VV | KV Mechelen | ||
| 05-07/02/2027 | KV Mechelen | Cercle Brugge KSV | ||
| 12-14/02/2027 | RSC Anderlecht | KV Mechelen | ||
| 19-21/02/2027 | KV Mechelen | SK Beveren | ||
| 26-28/02/2027 | KVC Westerlo | KV Mechelen | ||
| 05-07/03/2027 | KV Mechelen | KV Kortrijk | ||
| 12-14/03/2027 | R. Standard de Liège | KV Mechelen | ||
| 19-21/03/2027 | KV Mechelen | Sporting du Pays de Charleroi | ||
| 02-04/04/2027 | R. Union Saint-Gilloise | KV Mechelen | ||
| 09-11/04/2027 | KV Mechelen | KAA Gent | ||
| 16-18/04/2027 | KV Mechelen | Raal La Louvière | ||
| 23-25/04/2027 | SV Zulte Waregem | KV Mechelen | ||
| 30-04/02-05/2027 | KV Mechelen | R. Antwerp FC | ||
| 07-09/05/2027 | Club Brugge KV | KV Mechelen | ||
| 14-16/05/2027 | KV Mechelen | Oud-Heverlee Leuven | ||
| 21-23/05/2027 | KRC Genk | KV Mechelen |