| 26/07/2025 | SV Zulte Waregem | KV Mechelen | 1 – 1 | |
| 01/08/2025 | KV Mechelen | Club Brugge KV | 2 – 1 | eerste overwinning |
| 09/08/2025 | KVC Westerlo | KV Mechelen | 0 – 1 | |
| 16/08/2025 | KV Mechelen | KAA Gent | 1 – 1 | |
| 24/08/2025 | R. Antwerp FC | KV Mechelen | 2 – 1 | eerste nederlaag |
| 30/08/2025 | KV Mechelen | RAAL La Louvière | 3 – 2 | |
| 12/09/2025 | R. Standard de Liège | KV Mechelen | 1 – 1 | |
| 21/09/2025 | KV Mechelen | Cercle Brugge KSV | 0 – 0 | |
| 28/09/2025 | Sporting du Pays de Charleroi | KV Mechelen | 0 – 2 | |
| 04/10/2025 | KV Mechelen | K. Sint-Truidense VV | 1 – 3 | eerste thuisnederlaag |
| 19/10/2025 | FC Verbroedering Dender EH | KV Mechelen | ||
| 25/10/2025 | KV Mechelen | Oud-Heverlee Leuven | ||
| 01/11/2025 | RSC Anderlecht | KV Mechelen | ||
| 09/11/2025 | KV Mechelen | R. Union Saint-Gilloise | ||
| 23/11/2025 | KRC Genk | KV Mechelen | ||
| 28/11/2025 | KV Mechelen | R. Standard de Liège | ||
| 07/12/2025 | KV Mechelen | Sporting du Pays de Charleroi | ||
| 13/12/2025 | Cercle Brugge KSV | KV Mechelen | ||
| 21/12/2025 | K. Sint-Truidense VV | KV Mechelen | ||
| 27/12/2025 | KV Mechelen | FC Verbroedering Dender EH | ||
| 16-18/01/2026 | R. Union Saint-Gilloise | KV Mechelen | ||
| 23-25/01/2026 | KV Mechelen | KVC Westerlo | ||
| 30/01-01/02/2026 | Oud-Heverlee Leuven | KV Mechelen | ||
| 06-08/02/2026 | KV Mechelen | R. Antwerp FC | ||
| 13-15/02/2026 | KV Mechelen | KRC Genk | ||
| 20-22/02/2026 | RAAL La Louvière | KV Mechelen | ||
| 27/02-01/03/2026 | KV Mechelen | SV Zulte Waregem | ||
| 06-08/03/2026 | KAA Gent | KV Mechelen | ||
| 13-15/03/2026 | KV Mechelen | RSC Anderlecht | ||
| 20-22/03/2026 | Club Brugge KV | KV Mechelen |