| 26/07/2024 | Club Brugge KV | KV Mechelen | 1 – 1 | |
| 03/08/2024 | KV Mechelen | KVC Westerlo | 2 – 4 | eerste nederlaag |
| 09/08/2024 | R. Standard de Liège | KV Mechelen | 0 – 0 | |
| 17/08/2024 | KV Mechelen | RSC Anderlecht | 1 – 3 | |
| 24/08/2024 | R. Antwerp FC | KV Mechelen | 0 – 1 | eerste overwinning |
| 31/08/2024 | KV Mechelen | Sporting du Pays de Charleroi | 5 – 2 | |
| 15/09/2024 | KAA Gent | KV Mechelen | 2 – 0 | |
| 22/09/2024 | KV Mechelen | Cercle Brugge KSV | 2 – 0 | |
| 28/09/2024 | KRC Genk | KV Mechelen | 2 – 1 | |
| 05/10/2024 | KV Mechelen | Oud-Heverlee Leuven | 5 – 0 | grootste overwinning |
| 20/10/2024 | KV Mechelen | KV Kortrijk | 3 – 0 | grootste nederlaag |
| 26/10/2024 | FC Verbroedering Dender EH | KV Mechelen | 2 – 5 | |
| 02/11/2024 | KV Mechelen | R. Union Saint-Gilloise | 1 – 1 | |
| 08/11/2024 | K. Sint-Truidense VV | KV Mechelen | 2 – 1 | |
| 24/11/2024 | KV Mechelen | Beerschot VA | 3 – 0 | |
| 29/11/2024 | KV Kortrijk | KV Mechelen | 3 – 1 | |
| 07/12/2024 | KV Mechelen | Club Brugge KV | 1 – 2 | |
| 13/12/2024 | KV Mechelen | R. Antwerp FC | 1 – 1 | |
| 20/12/2024 | KVC Westerlo | KV Mechelen | 1 – 1 | |
| 26/12/2024 | KV Mechelen | R. Standard de Liège | 0 – 0 | |
| 12/01/2025 | Cercle Brugge KSV | KV Mechelen | 1 – 0 | |
| 18/01/2025 | KV Mechelen | KRC Genk | 1 – 2 | |
| 26/01/2025 | RSC Anderlecht | KV Mechelen | 4 – 1 | grootste nederlaag |
| 31/01/2025 | Oud-Heverlee Leuven | KV Mechelen | 1 – 0 | |
| 07/02/2025 | KV Mechelen | KAA Gent | 3 – 3 | |
| 16/02/2025 | R. Union Saint-Gilloise | KV Mechelen | 0 – 1 | |
| 21/02/2025 | KV Mechelen | K. Sint-Truidense VV | 1 – 1 | |
| 02/03/2025 | Beerschot VA | KV Mechelen | 1 – 0 | |
| 08/03/2025 | Sporting du Pays de Charleroi | KV Mechelen | 0 – 1 | |
| 16/03/2025 | KV Mechelen | FC Verbroedering Dender EH | 2 – 1 |