| 02/09/1972 | K. Beerschot VAV – KV Mechelen | 1 – 2 | eerste zege |
| 10/09/1972 | KV Mechelen – R. Crossing Club Schaerbeek | 0 – 1 | eerste nederlaag |
| 17/09/1972 | KV Mechelen – K. Beringen FC | 1 – 1 | |
| 23/09/1972 | RFC Liègeois – KV Mechelen | 1 – 1 | |
| 08/10/1972 | KV Mechelen – K. Berchem Sport | 1 – 0 | |
| 15/10/1972 | Club Brugge KV – KV Mechelen | 3 – 2 | |
| 22/10/1972 | KV Mechelen – K. Lierse SV | 4 – 1 | grootste zege |
| 28/10/1972 | K. Sint-Truidense VV – KV Mechelen | 2 – 2 | |
| 05/11/1972 | KV Mechelen – R. Racing White | 1 – 1 | |
| 12/11/1972 | RSC Anderlechtois – KV Mechelen | 1 – 1 | |
| 26/11/1972 | KV Mechelen – KFC Diest | 0 – 1 | |
| 03/12/1972 | R. Standard Club Liègeois – KV Mechelen | 3 – 0 | grootste nederlaag |
| 10/12/1972 | KV Mechelen – Union Saint-Gilloise | 1 – 0 | |
| 17/12/1972 | KV Mechelen – R. Antwerp FC | 2 – 0 | |
| 07/01/1973 | KSV Cercle Brugge – KV Mechelen | 2 – 3 | |
| 14/01/1973 | KV Mechelen – K. Beerschot VAV | 0 – 0 | |
| 21/01/1973 | R. Crossing Club Schaerbeek – KV Mechelen | 0 – 3 | grootste zege |
| 28/01/1973 | K. Beringen FC – KV Mechelen | 1 – 2 | |
| 04/02/1973 | KV Mechelen – RFC Liègeois | 2 – 2 | |
| 10/02/1973 | K. Berchem Sport – KV Mechelen | 0 – 0 | |
| 18/02/1973 | KV Mechelen – Club Brugge KV | 0 – 0 | |
| 03/03/1973 | K. Lierse SV – KV Mechelen | 1 – 1 | |
| 11/03/1973 | KV Mechelen – K. Sint-Truidense VV | 1 – 1 | |
| 18/03/1973 | R. Racing White – KV Mechelen | 0 – 0 | |
| 25/03/1973 | KV Mechelen – RSC Anderlechtois | 1 – 0 | |
| 01/04/1973 | KFC Diest – KV Mechelen | 1 – 1 | |
| 08/04/1973 | KV Mechelen – R. Standard Club Liègeois | 2 – 2 | |
| 15/04/1973 | Union Saint-Gilloise – KV Mechelen | 0 – 1 | |
| 29/04/1973 | R. Antwerp FC – KV Mechelen | 1 – 1 | |
| 06/05/1973 | KV Mechelen – KSV Cercle Brugge | 1 – 1 |
| eindklassement eerste afdeling | aantal | winst | gelijk | verlies | goals+ | goals- | ptn | |
| 1 | CLUB BRUGGE KONINKLIJKE VOETBALVERENIGING | 30 | 17 | 11 | 2 | 53 | 26 | 45 |
| 2 | Royal Standard Club Liègeois | 30 | 12 | 14 | 4 | 45 | 25 | 38 |
| 3 | Royal Racing White | 30 | 10 | 17 | 3 | 45 | 19 | 37 |
| 4 | Koninklijke Beerschot Voetbal- en Atletiekvereniging | 30 | 14 | 8 | 8 | 40 | 33 | 36 |
| 5 | Koninklijke Voetbalklub Mechelen | 30 | 10 | 16 | 4 | 37 | 28 | 36 |
| 6 | Royal Sporting Club Anderlechtois | 30 | 12 | 10 | 8 | 47 | 30 | 34 |
| 7 | Royal Antwerp Football Club | 30 | 13 | 5 | 12 | 43 | 38 | 31 |
| 8 | Koninklijk Berchem Sport | 30 | 11 | 9 | 10 | 28 | 28 | 31 |
| 9 | Koninklijke Lierse Sportvereniging | 30 | 10 | 11 | 9 | 43 | 43 | 31 |
| 10 | Royal Football Club Liègeois | 30 | 9 | 11 | 10 | 34 | 35 | 29 |
| 11 | Koninklijke Sportvereniging Cercle Brugge | 30 | 9 | 10 | 11 | 33 | 44 | 28 |
| 12 | Koninklijke Beringen Football Club | 30 | 8 | 10 | 12 | 28 | 39 | 26 |
| 13 | Koninklijke Sint-Truidense Voetbalvereniging | 30 | 6 | 13 | 11 | 31 | 41 | 25 |
| 14 | Koninklijke Football Club Diest | 30 | 8 | 5 | 17 | 30 | 51 | 21 |
| 15 | Union Saint-Gilloise | 30 | 4 | 11 | 15 | 17 | 38 | 19 |
| 16 | Royal Crossing Club Schaerbeek | 30 | 3 | 7 | 20 | 20 | 56 | 13 |