| 05/09/1965 | R. Daring Club de Bruxelles – KFC Malinois | 0 – 0 | |
| 12/09/1965 | KFC Malinois – RSC Anderlecht | 0 – 2 | |
| 19/09/1965 | KFC Malinois – R. Tilleur FC | 3 – 1 | |
| 03/10/1965 | R. Berchem Sport – KFC Malinois | 1 – 2 | |
| 10/10/1965 | KFC Malinois – K. Beeringen FC | 2 – 0 | |
| 17/10/1965 | R. Antwerp FC – KFC Malinois | 2 – 0 | |
| 31/10/1965 | KFC Malinois – R. Racing White | 2 – 0 | |
| 14/11/1965 | KFC Malinois – K. Sint-Truidense VV | 0 – 0 | |
| 21/11/1965 | K. Liersche SK – KFC Malinois | 1 – 2 | |
| 28/11/1965 | KFC Malinois – RCS Brugeois | 1 – 0 | |
| 05/12/1965 | R. Beerschot AC – KFC Malinois | 1 – 0 | |
| 12/12/1965 | KFC Malinois – RFC Liègeois | 6 – 2 | grootste zege |
| 19/12/1965 | RFC Brugeois – KFC Malinois | 2 – 0 | |
| 26/12/1965 | KFC Malinois – ARA La Gantoise | 0 – 3 | |
| 02/01/1966 | R. Standard Club Liègeois – KFC Malinois | 1 – 0 | |
| 09/01/1966 | KFC Malinois – R. Daring Club de Bruxelles | 1 – 0 | |
| 16/01/1966 | RSC Anderlechtois – KFC Malinois | 7 – 1 | grootste nederlaag |
| 22/01/1966 | R. Tilleur FC – KFC Malinois | 1 – 2 | |
| 30/01/1966 | KFC Malinois – R. Berchem Sport | 2 – 1 | |
| 06/02/1966 | K. Beeringen FC – KFC Malinois | 0 – 1 | |
| 13/02/1966 | KFC Malinois – R. Antwerp FC | 1 – 0 | |
| 20/02/1966 | R. Racing White – KFC Malinois | 1 – 0 | |
| 27/02/1966 | KFC Malinois – K. Liersche SK | 0 – 0 | |
| 06/03/1966 | RCS Brugeois – KFC Malinois | 0 – 0 | |
| 13/03/1966 | KFC Malinois – R. Beerschot AC | 2 – 2 | |
| 19/03/1966 | RFC Liègeois – KFC Malinois | 2 – 2 | |
| 27/03/1966 | KFC Malinois – RFC Brugeois | 1 – 5 | |
| 03/04/1966 | ARA La Gantoise – KFC Malinois | 2 – 3 | |
| 08/05/1966 | K. Sint-Truidense VV – KFC Malinois | 1 – 0 | |
| 15/05/1966 | KFC Malinois – R. Standard Club Liègeois | 1 – 1 |
| eindklassement eerste nationale | aantal | winst | gelijk | verlies | goals+ | goals- | ptn | |
| 1 | ROYAL SPORTING CLUB ANDERLECHTOIS | 30 | 21 | 5 | 4 | 88 | 18 | 47 |
| 2 | Koninklijke Sint-Truidense Voetbalvereniging | 30 | 18 | 4 | 8 | 43 | 29 | 40 |
| 3 | Royal Standard Club Liègeois | 30 | 16 | 8 | 6 | 47 | 24 | 40 |
| 4 | Royal Beerschot Athletic Club | 30 | 15 | 9 | 6 | 45 | 29 | 39 |
| 5 | Royal Football Club Brugeois | 30 | 12 | 11 | 7 | 56 | 39 | 35 |
| 6 | Koninklijke Football Club Malinois | 30 | 13 | 7 | 10 | 35 | 39 | 33 |
| 7 | Association Royale Athlétique La Gantoise | 30 | 11 | 8 | 11 | 47 | 62 | 30 |
| 8 | Royal Tilleur Football Club | 30 | 9 | 12 | 9 | 30 | 37 | 30 |
| 9 | Royal Football Club Liègeois | 30 | 11 | 7 | 12 | 52 | 46 | 29 |
| 10 | Royal Antwerp Football Club | 30 | 11 | 7 | 12 | 43 | 44 | 29 |
| 11 | Koninklijke Liersche Sportkring | 30 | 8 | 10 | 12 | 30 | 40 | 26 |
| 12 | Royal Racing White | 30 | 8 | 8 | 14 | 36 | 47 | 24 |
| 13 | Royal Daring Club Bruxelles | 30 | 7 | 10 | 13 | 25 | 31 | 24 |
| 14 | Koninklijke Beeringen Football Club | 30 | 7 | 6 | 17 | 29 | 51 | 20 |
| 15 | Royal Berchem Sport | 30 | 4 | 10 | 16 | 24 | 52 | 18 |
| 16 | Royal Cercle Sportif Brugeois | 30 | 5 | 6 | 19 | 19 | 61 | 16 |
Opmerking: RCS Brugeois degradeerde naar derde nationale!