| 24/07/2022 | KV Mechelen | R. Antwerp FC | 0 – 2 | eerste nederlaag |
| 30/07/2022 | KV Oostende | KV Mechelen | 2 – 1 | |
| 06/08/2022 | KV Mechelen | R. Union Saint-Gilloise | 3 – 0 | eerste overwinning |
| 13/08/2022 | Cercle Brugge KSV | KV Mechelen | 0 – 0 | |
| 21/08/2022 | KV Mechelen | KVC Westerlo | 5 – 4 | |
| 27/08/2022 | K. Sint-Truidense VV | KV Mechelen | 3 – 1 | |
| 03/09/2022 | KV Mechelen | FC Seraing | 2 – 3 | |
| 10/09/2022 | KV Kortrijk | KV Mechelen | 1 – 4 | grootste overwinning |
| 17/09/2022 | KV Mechelen | Oud-Heverlee Leuven | 0 – 0 | |
| 01/10/2022 | Club Brugge KV | KV Mechelen | 3 – 0 | |
| 09/10/2022 | KV Mechelen | RSC Anderlecht | 1 – 3 | |
| 16/10/2022 | KAA Gent | KV Mechelen | 3 – 0 | |
| 19/10/2022 | KV Mechelen | R. Standard de Liège | 2 – 0 | |
| 22/10/2022 | KV Mechelen | KAS Eupen | 2 – 1 | |
| 28/10/2022 | KRC Genk | KV Mechelen | 3 – 1 | |
| 05/11/2022 | KV Mechelen | SV Zulte- Waregem | 2 – 2 | |
| 12/11/2022 | Sporting du Pays de Charleroi | KV Mechelen | gestopt | na 68′ bij 1-0 |
| 23/12/2022 | KV Mechelen | Cercle Brugge KSV | 1 – 1 | |
| 08/01/2023 | SV Zulte-Waregem | KV Mechelen | 2 – 0 | |
| 14/01/2023 | KV Mechelen | KV Oostende | 2 – 1 | |
| 17/01/2023 | R. Standard de Liège | KV Mechelen | 2 – 0 | |
| 21/01/2023 | KV Mechelen | KV Kortrijk | 3 – 2 | |
| 28/01/2023 | KVC Westerlo | KV Mechelen | 2 – 0 | |
| 05/02/2023 | KV Mechelen | Sporting du Pays de Charleroi | 2 – 2 | |
| 10/02/2023 | KAS Eupen | KV Mechelen | 2 – 1 | |
| 17/02/2023 | KV Mechelen | KRC Genk | 2 – 2 | |
| 25/02/2023 | FC Seraing | KV Mechelen | 0 – 2 | |
| 05/03/2023 | R. Antwerp FC | KV Mechelen | 5 – 0 | grootste nederlaag |
| 11/03/2023 | KV Mechelen | K. Sint-Truidense VV | 1 – 0 | |
| 19/03/2023 | R. Union Saint-Gilloise | KV Mechelen | 2 – 1 | |
| 02/04/2023 | KV Mechelen | Club Brugge KV | ||
| 08/04/2023 | Oud-Heverlee Leuven | KV Mechelen | ||
| 16/04/2023 | KV Mechelen | KAA Gent | ||
| 23/04/2023 | RSC Anderlecht | KV Mechelen |
